???
??
???®?Mabthera®???????®? ???®(?????)???????????????????????NHL?????????????????????SFDA???????®???? ??CHOP*??8????????????B?????? ??CVP**??8????????????????? ????????????B???????????
??
??? ???®??????20?????????????????????????????????????????1,2?
 ??o 3?????? 62 % (R-CHOP) vs. 51 % (CHOP) ??o 5????? ?58% (R-CHOP) vs. 45% (CHOP)
 ??? ????????????????????????????®??CHOP (R-CHOP)????55%????4??7????????2????????100%?63%?????37%?????
??? ?????????????????????®?? CVP?R-CVP??CVP ????????????????????????????????????????R-CVP??????CVP????????(27?? vs. 7 ??)???????? (32 ?? vs 15??)?????(81% vs 57%) ??????(41% vs 10%)? ????????????

    ????????????????????,?????????197?WG?MPA????????????????????????4????????????????????????6?????????????????????????64%?????????

    ????????????????????????????????????????????????WG?MPA??????????????????????????????????????????????????

     FDA????????(?????)??????(???)??????????(WG)???????(MPA)?????????????????????

    WG?MPA????????????????????????????????????????2???????